Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

Doser, Thomas A; Turdi, Subat; Thomas, D Paul; Epstein, Paul N; Li, Shi-Yan; Ren, Jun

Doser, Thomas A; Turdi, Subat; Thomas, D Paul; Epstein, Paul N; Li, Shi-Yan; Ren, Jun.

Affiliation

Doser TA; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.

Circulation ; 119(14): 1941-9, 2009 Apr 14.

Article in En | MEDLINE | ID: mdl-19332462

Subject(s)

Alcoholism/complications; Aldehyde Dehydrogenase/genetics; Cardiomegaly/prevention & control; Myocardial Contraction/genetics; Acetaldehyde/blood; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cloning, Molecular; DNA Damage; Echocardiography; Ethanol/blood; Gene Expression Regulation, Enzymologic; Heart/physiopathology; Humans; Mice; Mice, Transgenic; Myocardium/pathology; Myocytes, Cardiac/physiology; Plasmids; Restriction Mapping

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Full text: 1 Database: MEDLINE Main subject: Cardiomegaly / Alcoholism / Aldehyde Dehydrogenase / Myocardial Contraction Limits: Animals / Humans Language: En Year: 2009 Type: Article

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