Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

Milenic, D E; Yokota, T; Filpula, D R; Finkelman, M A; Dodd, S W; Wood, J F; Whitlow, M; Snoy, P; Schlom, J

Milenic, D E; Yokota, T; Filpula, D R; Finkelman, M A; Dodd, S W; Wood, J F; Whitlow, M; Snoy, P; Schlom, J.

Affiliation

Milenic DE; Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Cancer Res ; 51(23 Pt 1): 6363-71, 1991 Dec 01.

Article in En | MEDLINE | ID: mdl-1933899

Subject(s)

Antibodies, Monoclonal/metabolism; Colonic Neoplasms/therapy; Immunoglobulin Fab Fragments/metabolism; Immunoglobulin G/metabolism; Recombinant Proteins/pharmacokinetics; Animals; Colonic Neoplasms/metabolism; Electrophoresis, Polyacrylamide Gel; Female; Immunoenzyme Techniques; Iodine Radioisotopes/metabolism; Macaca mulatta; Mice; Mice, Nude; Molecular Weight; Radioimmunoassay; Recombinant Proteins/chemical synthesis; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Tissue Distribution

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Recombinant Proteins / Immunoglobulin G / Immunoglobulin Fab Fragments / Colonic Neoplasms / Antibodies, Monoclonal Limits: Animals Language: En Year: 1991 Type: Article

Search on Google

XML

PubMed Links