Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.

Talyzina, Nina M; Ingvarsson, Pär K; Zhu, Jun; Wai, Sun N; Andersson, Agneta

Talyzina, Nina M; Ingvarsson, Pär K; Zhu, Jun; Wai, Sun N; Andersson, Agneta.

Affiliation

Talyzina NM; Department of Ecology and Environmental Science, Umeå University, Sweden. nina.talyzina@emg.umu.se

Appl Environ Microbiol ; 75(11): 3808-12, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19346342

ABSTRACT

ABSTRACT

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

Subject(s)

Bacterial Proteins/genetics; Cholera/microbiology; Quorum Sensing; Selection, Genetic; Vibrio cholerae O139/physiology; Vibrio cholerae O1/physiology; Vibrio cholerae non-O1/physiology; Cholera/epidemiology; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; Disease Outbreaks; Gene Expression Regulation; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Analysis, DNA; Vibrio cholerae O1/genetics; Vibrio cholerae O139/genetics; Vibrio cholerae non-O1/genetics

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Full text: 1 Database: MEDLINE Main subject: Selection, Genetic / Bacterial Proteins / Cholera / Vibrio cholerae O1 / Vibrio cholerae O139 / Vibrio cholerae non-O1 / Quorum Sensing Language: En Year: 2009 Type: Article

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