Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts.

Burke, J P; Watson, R W G; Murphy, M; Docherty, N G; Coffey, J C; O'Connell, P R

Burke, J P; Watson, R W G; Murphy, M; Docherty, N G; Coffey, J C; O'Connell, P R.

Affiliation

Burke JP; Department of Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.

Br J Surg ; 96(5): 541-51, 2009 May.

Article in En | MEDLINE | ID: mdl-19358180

Subject(s)

Colon/cytology; Fibroblasts/drug effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Simvastatin/pharmacology; Smad3 Protein/metabolism; Transforming Growth Factor beta1/drug effects; Actins/metabolism; Blotting, Western; Cell Communication; Cells, Cultured; Connective Tissue Growth Factor/metabolism; Enzyme-Linked Immunosorbent Assay; Fibroblasts/physiology; Humans; Microscopy, Confocal; Phosphorylation/drug effects; Plasminogen Activator Inhibitor 1/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1/physiology

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Full text: 1 Database: MEDLINE Main subject: Colon / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Smad3 Protein / Transforming Growth Factor beta1 / Fibroblasts Type of study: Prognostic_studies Limits: Humans Language: En Year: 2009 Type: Article

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