In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

Coughlan, Lynda; Vallath, Sabari; Saha, Antonio; Flak, Magdalena; McNeish, Iain A; Vassaux, Georges; Marshall, John F; Hart, Ian R; Thomas, Gareth J

Coughlan, Lynda; Vallath, Sabari; Saha, Antonio; Flak, Magdalena; McNeish, Iain A; Vassaux, Georges; Marshall, John F; Hart, Ian R; Thomas, Gareth J.

Affiliation

Coughlan L; Centre for Tumour Biology, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom. l.t.coughlan@qmul.ac.uk

J Virol ; 83(13): 6416-28, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19369326

Subject(s)

Adenoviridae/genetics; Antigens, Neoplasm/metabolism; Genetic Therapy/methods; Genetic Vectors; Integrins/metabolism; Oncolytic Virotherapy; Animals; Capsid Proteins/genetics; Capsid Proteins/metabolism; Cell Line, Tumor; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Female; Genome, Viral; Humans; Mice; Mice, Nude; Protein Binding; Receptors, Virus/metabolism; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Saccharomyces cerevisiae/genetics

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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / Integrins / Adenoviridae / Oncolytic Virotherapy / Genetic Vectors / Antigens, Neoplasm Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2009 Type: Article

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