The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.

Krämer, Stephanie; Binder, Eva; Loof, Tanja; Wang-Rosenke, Yingrui; Martini, Sebastian; Khadzhynov, Dmytro; Budde, Klemens; Neumayer, Hans-H; Peters, Harm

Krämer, Stephanie; Binder, Eva; Loof, Tanja; Wang-Rosenke, Yingrui; Martini, Sebastian; Khadzhynov, Dmytro; Budde, Klemens; Neumayer, Hans-H; Peters, Harm.

Affiliation

Krämer S; Department of Nephrology and Center for Cardiovascular Research, Charité Universitätsmedizin Berlin, Charité Campus Mitte, Humboldt University Berlin, D-10117 Berlin, Germany.

Am J Physiol Renal Physiol ; 297(1): F218-27, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19439518

Subject(s)

Cell Movement/physiology; Hypertension/drug therapy; Immunosuppressive Agents/therapeutic use; Kidney Diseases/drug therapy; Kidney Diseases/pathology; Lymphocytes/pathology; Propylene Glycols/therapeutic use; Sphingosine/analogs & derivatives; Animals; Blood Pressure/drug effects; Blood Pressure/physiology; Cell Movement/drug effects; Cell Proliferation/drug effects; Disease Models, Animal; Extracellular Matrix/drug effects; Extracellular Matrix/metabolism; Fibrosis; Fingolimod Hydrochloride; Hypertension/complications; Immunosuppressive Agents/pharmacology; Kidney/pathology; Kidney Diseases/etiology; Lymphocytes/drug effects; Macrophages/drug effects; Macrophages/pathology; Male; Nephrectomy; Propylene Glycols/pharmacology; Proteinuria/drug therapy; Rats; Rats, Wistar; Sphingosine/pharmacology; Sphingosine/therapeutic use; Transforming Growth Factor beta/metabolism

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Full text: 1 Database: MEDLINE Main subject: Propylene Glycols / Sphingosine / Lymphocytes / Cell Movement / Hypertension / Immunosuppressive Agents / Kidney Diseases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Year: 2009 Type: Article

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