Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models.
J Med Food
; 12(2): 278-91, 2009 Apr.
Article
in En
| MEDLINE
| ID: mdl-19459727
ABSTRACT
Local food diversity and traditional crops are essential for cost-effective management of the global epidemic of type 2 diabetes and associated complications of hypertension. Water and 12% ethanol extracts of native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipeña (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), and Algarrobo (Prosopis pallida) were evaluated for total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolic content ranged from 3.2 (Aguaymanto) to 11.4 (Lucuma fruit) mg/g of sample dry weight. A significant positive correlation was found between total phenolic content and antioxidant activity for the ethanolic extracts. No phenolic compound was detected in Lucuma (fruit and powder) and Pacae. Aqueous extracts from Lucuma and Algarrobo had the highest alpha-glucosidase inhibitory activities. Papayita arequipeña and Algarrobo had significant ACE inhibitory activities reflecting antihypertensive potential. These in vitro results point to the excellent potential of Peruvian fruits for food-based strategies for complementing effective antidiabetes and antihypertension solutions based on further animal and clinical studies.
Full text:
1
Database:
MEDLINE
Main subject:
Phenols
/
Angiotensin-Converting Enzyme Inhibitors
/
Plant Extracts
/
Diabetes Mellitus, Type 2
/
Glycoside Hydrolase Inhibitors
/
Hypoglycemic Agents
/
Antihypertensive Agents
Type of study:
Evaluation_studies
Country/Region as subject:
America do sul
/
Peru
Language:
En
Year:
2009
Type:
Article