The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.

Kumari, Daman; Somma, Valentina; Nakamura, Asako J; Bonner, William M; D'Ambrosio, Ettoré; Usdin, Karen

Kumari, Daman; Somma, Valentina; Nakamura, Asako J; Bonner, William M; D'Ambrosio, Ettoré; Usdin, Karen.

Affiliation

Kumari D; Section on Gene Structure and Disease, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, USA.

Nucleic Acids Res ; 37(13): 4385-92, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19465392

Subject(s)

Cell Cycle Proteins/metabolism; Chromosome Fragile Sites; Chromosome Fragility; DNA Damage; DNA-Binding Proteins/metabolism; Fragile X Syndrome/genetics; Protein Serine-Threonine Kinases/metabolism; Tumor Suppressor Proteins/metabolism; Aphidicolin/pharmacology; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/genetics; Cell Line; Chromosome Breakage; DNA Repair; DNA-Binding Proteins/antagonists & inhibitors; Floxuridine/pharmacology; Fragile X Mental Retardation Protein/genetics; Fragile X Syndrome/enzymology; Gene Knockdown Techniques; Histones/analysis; Humans; Male; Morpholines/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/genetics; Pyrones/pharmacology; Staurosporine/analogs & derivatives; Staurosporine/pharmacology; Tumor Suppressor Proteins/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Chromosome Fragility / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Tumor Suppressor Proteins / Chromosome Fragile Sites / DNA-Binding Proteins / Fragile X Syndrome Limits: Humans / Male Language: En Year: 2009 Type: Article

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