Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse.
Neurosci Lett
; 460(2): 130-2, 2009 Aug 28.
Article
in En
| MEDLINE
| ID: mdl-19477225
ABSTRACT
Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.
Full text:
1
Database:
MEDLINE
Main subject:
Brain-Derived Neurotrophic Factor
/
Multiple Sclerosis
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2009
Type:
Article