The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

Costantino, Christina L; Witkiewicz, Agnieszka K; Kuwano, Yuki; Cozzitorto, Joseph A; Kennedy, Eugene P; Dasgupta, Abhijit; Keen, Judith C; Yeo, Charles J; Gorospe, Myriam; Brody, Jonathan R

Costantino, Christina L; Witkiewicz, Agnieszka K; Kuwano, Yuki; Cozzitorto, Joseph A; Kennedy, Eugene P; Dasgupta, Abhijit; Keen, Judith C; Yeo, Charles J; Gorospe, Myriam; Brody, Jonathan R.

Affiliation

Costantino CL; Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Departments of Pathology and Pharmacology and Experimental Therapeutics, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Cancer Res ; 69(11): 4567-72, 2009 Jun 01.

Article in En | MEDLINE | ID: mdl-19487279

Subject(s)

Antigens, Surface/physiology; Carcinoma, Pancreatic Ductal/drug therapy; Carcinoma, Pancreatic Ductal/genetics; Deoxycytidine Kinase/genetics; Deoxycytidine/analogs & derivatives; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/genetics; RNA-Binding Proteins/physiology; Antigens, Surface/genetics; Antimetabolites, Antineoplastic/therapeutic use; Biomarkers, Tumor/genetics; Biomarkers, Tumor/physiology; Cytarabine/therapeutic use; Deoxycytidine/pharmacokinetics; Deoxycytidine/therapeutic use; Deoxycytidine Kinase/metabolism; Drug Resistance, Neoplasm/genetics; ELAV Proteins; ELAV-Like Protein 1; Gene Expression Regulation, Neoplastic/drug effects; Humans; Inactivation, Metabolic/genetics; RNA-Binding Proteins/genetics; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Up-Regulation/drug effects; Gemcitabine

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / RNA-Binding Proteins / Carcinoma, Pancreatic Ductal / Deoxycytidine / Deoxycytidine Kinase / Antigens, Surface Limits: Humans Language: En Year: 2009 Type: Article

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