Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Bagdanoff, Jeffrey T; Donoviel, Michael S; Nouraldeen, Amr; Tarver, James; Fu, Qinghong; Carlsen, Marianne; Jessop, Theodore C; Zhang, Haiming; Hazelwood, Jill; Nguyen, Huy; Baugh, Simon D P; Gardyan, Michael; Terranova, Kristen M; Barbosa, Joseph; Yan, Jack; Bednarz, Mark; Layek, Suman; Courtney, Lawrence F; Taylor, Jerry; Digeorge-Foushee, Ann Marie; Gopinathan, Suma; Bruce, Debra; Smith, Traci; Moran, Liam; O'Neill, Emily; Kramer, Jeff; Lai, Zhong; Kimball, S David; Liu, Qingyun; Sun, Weimei; Yu, Sean; Swaffield, Jonathan; Wilson, Alan; Main, Alan; Carson, Kenneth G; Oravecz, Tamas; Augeri, David J

Bagdanoff, Jeffrey T; Donoviel, Michael S; Nouraldeen, Amr; Tarver, James; Fu, Qinghong; Carlsen, Marianne; Jessop, Theodore C; Zhang, Haiming; Hazelwood, Jill; Nguyen, Huy; Baugh, Simon D P; Gardyan, Michael; Terranova, Kristen M; Barbosa, Joseph; Yan, Jack; Bednarz, Mark; Layek, Suman; Courtney, Lawrence F; Taylor, Jerry; Digeorge-Foushee, Ann Marie; Gopinathan, Suma; Bruce, Debra; Smith, Traci; Moran, Liam; O'Neill, Emily; Kramer, Jeff; Lai, Zhong; Kimball, S David; Liu, Qingyun; Sun, Weimei; Yu, Sean; Swaffield, Jonathan; Wilson, Alan; Main, Alan; Carson, Kenneth G; Oravecz, Tamas; Augeri, David J.

Affiliation

Bagdanoff JT; Lexicon Pharmaceuticals, Princeton, New Jersey, USA. jbagdanoff@lexpharma.com

J Med Chem ; 52(13): 3941-53, 2009 Jul 09.

Article in En | MEDLINE | ID: mdl-19489538

Subject(s)

Aldehyde-Lyases/antagonists & inhibitors; Autoimmune Diseases/drug therapy; Imidazoles/pharmacology; Administration, Oral; Animals; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Imidazoles/administration & dosage; Imidazoles/therapeutic use; Lymphocyte Count; Mice; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Autoimmune Diseases / Aldehyde-Lyases / Imidazoles Limits: Animals Language: En Year: 2009 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Autoimmune Diseases / Aldehyde-Lyases / Imidazoles Limits: Animals Language: En Year: 2009 Type: Article