IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge.

McKinstry, K Kai; Strutt, Tara M; Buck, Amanda; Curtis, Jonathan D; Dibble, John P; Huston, Gail; Tighe, Michael; Hamada, Hiromasa; Sell, Stewart; Dutton, Richard W; Swain, Susan L

McKinstry, K Kai; Strutt, Tara M; Buck, Amanda; Curtis, Jonathan D; Dibble, John P; Huston, Gail; Tighe, Michael; Hamada, Hiromasa; Sell, Stewart; Dutton, Richard W; Swain, Susan L.

Affiliation

McKinstry KK; Trudeau Institute, Saranac Lake, NY 12983, USA.

J Immunol ; 182(12): 7353-63, 2009 Jun 15.

Article in En | MEDLINE | ID: mdl-19494257

Subject(s)

Influenza A Virus, H1N1 Subtype/immunology; Interleukin-10/deficiency; Interleukin-10/immunology; Interleukin-17/immunology; Orthomyxoviridae Infections/immunology; T-Lymphocytes, Helper-Inducer/immunology; Animals; Antigens, Viral/immunology; Forkhead Transcription Factors/immunology; Interleukin-10/genetics; Interleukin-10/metabolism; Mice; Orthomyxoviridae Infections/genetics; Orthomyxoviridae Infections/metabolism; Survival Rate

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Full text: 1 Database: MEDLINE Main subject: Interleukin-10 / T-Lymphocytes, Helper-Inducer / Orthomyxoviridae Infections / Interleukin-17 / Influenza A Virus, H1N1 Subtype Limits: Animals Language: En Year: 2009 Type: Article

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