New families of enantiopure cyclohexenone cis-diol, o-quinol dimer and hydrate metabolites from dioxygenase-catalysed dihydroxylation of phenols.

Boyd, Derek R; Sharma, Narain D; Malone, John F; Allen, Christopher C R

Boyd, Derek R; Sharma, Narain D; Malone, John F; Allen, Christopher C R.

Affiliation

Boyd DR; School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UKBT9 5AG. dr.boyd@qub.ac.uk

Chem Commun (Camb) ; (24): 3633-5, 2009 Jun 28.

Article in En | MEDLINE | ID: mdl-19521632

ABSTRACT

ABSTRACT

Toluene dioxygenase-catalysed cis-dihydroxylation of phenols has led to the discovery of new enantiopure cyclohexenone cis-diol, o-quinol dimer and phenol hydrate metabolites having synthetic potential.

Subject(s)

Biocatalysis; Cyclohexanones/chemical synthesis; Dioxygenases/metabolism; Hydroquinones/chemistry; Phenols/chemistry; Phenols/metabolism; Water/chemistry; Crystallography, X-Ray; Cyclohexanones/chemistry; Dimerization; Models, Molecular; Molecular Structure; Stereoisomerism

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Full text: 1 Database: MEDLINE Main subject: Phenols / Water / Cyclohexanones / Dioxygenases / Biocatalysis / Hydroquinones Language: En Year: 2009 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Phenols / Water / Cyclohexanones / Dioxygenases / Biocatalysis / Hydroquinones Language: En Year: 2009 Type: Article