Drug-drug interactions involving new antiretroviral drugs and drug classes.

ABSTRACT

PURPOSE OF REVIEW The aim of this article is to review the available data on new antiretroviral agents and the drug-drug interactions studied so far. RECENT FINDINGS: Several new drugs have been recently approved or are under development for the treatment of HIV infection. The pharmacokinetics of these agents is being studied to provide information about safety and efficacy, and particularly about drug-drug interactions with antiretrovirals as well as with other drugs used in HIV patients to treat comorbidities. SUMMARY: Several agents for the treatment of HIV infection are under development. With new agents being used, new drug interaction mechanisms emerge and may lead to unpredictable outcomes. When drug-drug interactions are clinically significant, dose adjustments are required to prevent toxicity and ensure virological response.