Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
Diabetologia
; 52(9): 1866-70, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19533084
ABSTRACT
AIMS/HYPOTHESIS:
Variation in fasting plasma glucose (FPG) within the normal range is a known risk factor for the development of type 2 diabetes. Several reports have shown that genetic variation in the genes for glucokinase (GCK), glucokinase regulatory protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG. In this study we examined whether these loci also contribute to type 2 diabetes susceptibility.METHODS:
A random selection from the Dutch New Hoorn Study was used for replication of the association with FGP (2,361 non-diabetic participants). For the genetic association study we extended the study sample with 2,628 participants with type 2 diabetes. Risk allele counting was used to calculate a four-gene risk allele score for each individual.RESULTS:
Variants of the GCK, G6PC2 and MTNR1B genes but not GCKR were associated with FPG (all, pCONCLUSIONS:
A combined risk allele score for single-nucleotide polymorphisms in four known FPG loci is significantly associated with FPG and HbA(1c) in a Dutch population-based sample of non-diabetic participants. Carriers of low or high numbers of risk alleles show significantly different risks for type 2 diabetes compared with the reference group.
Full text:
1
Database:
MEDLINE
Main subject:
Blood Glucose
/
Glucose-6-Phosphatase
/
Polymorphism, Single Nucleotide
/
Receptor, Melatonin, MT2
/
Adaptor Proteins, Signal Transducing
/
Diabetes Mellitus, Type 2
/
Glucokinase
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2009
Type:
Article