CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase.

Mizuguchi, Shinjiro; Stephen, Jancy; Bihari, Relka; Markovic, Nevena; Suehiro, Shigefumi; Capretta, Alfredo; Potter, Richard F; Cepinskas, Gediminas

Mizuguchi, Shinjiro; Stephen, Jancy; Bihari, Relka; Markovic, Nevena; Suehiro, Shigefumi; Capretta, Alfredo; Potter, Richard F; Cepinskas, Gediminas.

Affiliation

Mizuguchi S; Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada N6A 4G4.

Am J Physiol Heart Circ Physiol ; 297(3): H920-9, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19561312

Subject(s)

Carbon Monoxide/pharmacology; Leukocyte Elastase/metabolism; Neutrophils/drug effects; Neutrophils/enzymology; Organometallic Compounds/pharmacology; Sepsis/drug therapy; Animals; Cell Adhesion/drug effects; Cell Adhesion/immunology; Cell Migration Assays, Leukocyte; Cell Movement/drug effects; Cell Movement/immunology; Cells, Cultured; Disease Models, Animal; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/immunology; Endothelium, Vascular/cytology; Endothelium, Vascular/immunology; Humans; Lipopolysaccharides/pharmacology; Lung/cytology; Lung/immunology; Mice; Mice, Inbred C57BL; Peritonitis/drug therapy; Peritonitis/immunology; Reactive Oxygen Species/metabolism; Sepsis/immunology; Umbilical Veins/cytology

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Full text: 1 Database: MEDLINE Main subject: Organometallic Compounds / Carbon Monoxide / Sepsis / Leukocyte Elastase / Neutrophils Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2009 Type: Article

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