The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors.

Seo, Seungmae; Henry, Jonathan T; Lewis, Amanda H; Wang, Nan; Levandoski, Mark M

Seo, Seungmae; Henry, Jonathan T; Lewis, Amanda H; Wang, Nan; Levandoski, Mark M.

Affiliation

Seo S; Department of Chemistry, Grinnell College, Grinnell, Iowa 50112, USA.

J Neurosci ; 29(27): 8734-42, 2009 Jul 08.

Article in En | MEDLINE | ID: mdl-19587280

Subject(s)

Morantel/metabolism; Neurons/metabolism; Protein Subunits/metabolism; Receptors, Nicotinic/metabolism; Allosteric Regulation/drug effects; Allosteric Regulation/genetics; Animals; Evoked Potentials/drug effects; Evoked Potentials/genetics; Female; Morantel/pharmacology; Neurons/drug effects; Neurons/physiology; Protein Binding/drug effects; Protein Binding/genetics; Protein Subunits/genetics; Protein Subunits/physiology; Rats; Receptors, Nicotinic/genetics; Receptors, Nicotinic/physiology; Xenopus laevis

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Full text: 1 Database: MEDLINE Main subject: Receptors, Nicotinic / Protein Subunits / Morantel / Neurons Limits: Animals Language: En Year: 2009 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, Nicotinic / Protein Subunits / Morantel / Neurons Limits: Animals Language: En Year: 2009 Type: Article