Circulating tumor cells and bone metastases as detected by FDG-PET/CT in patients with metastatic breast cancer.
Ann Oncol
; 21(1): 33-9, 2010 Jan.
Article
in En
| MEDLINE
| ID: mdl-19602564
ABSTRACT
BACKGROUND:
We evaluated the relationship between the detection and prognostic significance of circulating tumor cells (CTCs) and sites of metastases detected by 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in patients with metastatic breast cancer (MBC). PATIENTS ANDMETHODS:
From May 2004 to January 2008, 195 patients with relapsed/progressive MBC underwent whole-body FDG-PET/CT and provided blood samples for assessment of CTC count.RESULTS:
Higher CTC numbers were detected in patients with bone metastases relative to those with no bone lesions (mean 65.7 versus 3.3, P = 0.0122) and in patients with multiple bone metastases relative to those with one or two bone lesions (mean 77.7 versus 2.6, P < 0.001). CTCs predicted overall survival (OS) in 108 patients with multiple sites of metastases including bone (P = 0.0008) but not in 58 without bone metastases (P = 0.4111) and in 29 with bone involvement only (P = 0.3552). All 15 patients but one with human epidermal growth factor receptor 2 (HER-2) positive tumors who were treated with trastuzumab-based regimens had <5 CTCs at progression. In multivariate analysis, CTCs, but not bone metastases, remained a significant predictor of OS.CONCLUSION:
Presence of extensive bone metastases as detected by FDG-PET/CT is associated with increased CTC numbers in MBC.
Full text:
1
Database:
MEDLINE
Main subject:
Bone Neoplasms
/
Breast Neoplasms
/
Neoplastic Cells, Circulating
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Year:
2010
Type:
Article