Epithelial cells as immune effector cells: the role of CD40.
Semin Immunol
; 21(5): 289-92, 2009 Oct.
Article
in En
| MEDLINE
| ID: mdl-19628407
ABSTRACT
Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.
Full text:
1
Database:
MEDLINE
Main subject:
CD40 Antigens
/
Epithelial Cells
Limits:
Animals
/
Humans
Language:
En
Year:
2009
Type:
Article