4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents.

Duan, Maosheng; Aquino, Christopher; Dorsey, George F; Ferris, Robert; Kazmierski, Wieslaw M

Duan, Maosheng; Aquino, Christopher; Dorsey, George F; Ferris, Robert; Kazmierski, Wieslaw M.

Affiliation

Duan M; Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. maosheng.a.duan@gsk.com

Bioorg Med Chem Lett ; 19(17): 4988-92, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19664920

Subject(s)

Anti-HIV Agents/chemical synthesis; CCR5 Receptor Antagonists; Cyclohexylamines/chemical synthesis; Anti-HIV Agents/chemistry; Anti-HIV Agents/pharmacology; Cell Line, Tumor; Cyclohexylamines/chemistry; Cyclohexylamines/pharmacology; HIV Infections/drug therapy; Humans; Receptors, CCR5/metabolism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Anti-HIV Agents / Cyclohexylamines / CCR5 Receptor Antagonists Limits: Humans Language: En Year: 2009 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Anti-HIV Agents / Cyclohexylamines / CCR5 Receptor Antagonists Limits: Humans Language: En Year: 2009 Type: Article