Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.

Switzer, C H; Ridnour, L A; Cheng, R Y S; Sparatore, A; Del Soldato, P; Moody, T W; Vitek, M P; Roberts, D D; Wink, D A

Switzer, C H; Ridnour, L A; Cheng, R Y S; Sparatore, A; Del Soldato, P; Moody, T W; Vitek, M P; Roberts, D D; Wink, D A.

Affiliation

Switzer CH; Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Oncogene ; 28(43): 3837-46, 2009 Oct 29.

Article in En | MEDLINE | ID: mdl-19701246

Subject(s)

Anticarcinogenic Agents/pharmacology; Breast Neoplasms/drug therapy; Lung Neoplasms/drug therapy; Protein Phosphatase 2/metabolism; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Signal Transduction/drug effects; Breast Neoplasms/pathology; Cell Line, Tumor; Female; Humans; Lung Neoplasms/pathology; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Signal Transduction / Anticarcinogenic Agents / Proto-Oncogene Proteins c-akt / Protein Phosphatase 2 / Lung Neoplasms Limits: Female / Humans Language: En Year: 2009 Type: Article

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