The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.

Ponnamperuma, Roshini M; King, Kathryn E; Elsir, Tamador; Glick, Adam B; Wahl, Geoffrey M; Nister, Monica; Weinberg, Wendy C

Ponnamperuma, Roshini M; King, Kathryn E; Elsir, Tamador; Glick, Adam B; Wahl, Geoffrey M; Nister, Monica; Weinberg, Wendy C.

Affiliation

Ponnamperuma RM; Food and Drug Administration, Bethesda, MD 20892, USA.

J Pathol ; 219(2): 263-74, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19718706

Subject(s)

Carcinoma, Squamous Cell/prevention & control; Cell Transformation, Neoplastic/genetics; Genes, p53/genetics; Skin Neoplasms/prevention & control; Transforming Growth Factor beta/physiology; Animals; Carcinoma, Squamous Cell/genetics; Cells, Cultured; Cellular Senescence/genetics; Genotype; Keratinocytes/transplantation; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Skin Neoplasms/genetics; Transcriptional Activation/genetics; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/physiology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Skin Neoplasms / Carcinoma, Squamous Cell / Cell Transformation, Neoplastic / Genes, p53 / Transforming Growth Factor beta Type of study: Prognostic_studies Limits: Animals Language: En Year: 2009 Type: Article

Fulltext

XML

PubMed Links

Search on Google