Antineoplastic Agents/administration & dosage; Benzimidazoles/administration & dosage; Carcinoma, Basal Cell/drug therapy; Hedgehog Proteins/antagonists & inhibitors; Skin Neoplasms/drug therapy; Adult; Aged; Aged, 80 and over; Anilides; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Benzimidazoles/adverse effects; Benzimidazoles/pharmacokinetics; Carcinoma, Basal Cell/genetics; Carcinoma, Basal Cell/secondary; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Male; Middle Aged; Mutation; Patched Receptors; Patched-1 Receptor; Polymerase Chain Reaction; Pyridines; RNA, Messenger/metabolism; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Sequence Analysis, DNA; Signal Transduction/drug effects; Skin Neoplasms/genetics; Skin Neoplasms/pathology; Transcription Factors/genetics; Transcription Factors/metabolism; Zinc Finger Protein GLI1