Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma.

Kariyawasam, Harsha H; Pegorier, Sophie; Barkans, Julia; Xanthou, Georgina; Aizen, Maxine; Ying, Sun; Kay, A Barry; Lloyd, Clare M; Robinson, Douglas S

Kariyawasam, Harsha H; Pegorier, Sophie; Barkans, Julia; Xanthou, Georgina; Aizen, Maxine; Ying, Sun; Kay, A Barry; Lloyd, Clare M; Robinson, Douglas S.

Affiliation

Kariyawasam HH; Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.

J Allergy Clin Immunol ; 124(3): 454-62, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19733294

Subject(s)

Activins/biosynthesis; Allergens/immunology; Asthma/immunology; Bronchial Provocation Tests; Transforming Growth Factor beta/biosynthesis; Activin Receptors, Type I/immunology; Activin Receptors, Type I/metabolism; Activin Receptors, Type II/immunology; Activin Receptors, Type II/metabolism; Adult; Cell Proliferation/drug effects; Cells, Cultured; Cytokines/immunology; Cytokines/metabolism; Epithelial Cells/immunology; Epithelial Cells/metabolism; Follistatin/immunology; Follistatin/metabolism; Follistatin/pharmacology; Humans; Interleukin-13/pharmacology; Middle Aged; Receptors, Transforming Growth Factor beta/immunology; Receptors, Transforming Growth Factor beta/metabolism; Signal Transduction/drug effects; Signal Transduction/immunology; Smad2 Protein/immunology; Smad2 Protein/metabolism; Tumor Necrosis Factor-alpha/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Asthma / Bronchial Provocation Tests / Allergens / Transforming Growth Factor beta / Activins Type of study: Prognostic_studies Limits: Adult / Humans / Middle aged Language: En Year: 2009 Type: Article

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