Suppressor cell clones specific for ultraviolet radiation-induced tumors. Function and surface proteins.
J Immunol
; 145(7): 2044-9, 1990 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-1975821
ABSTRACT
Lymphocytes were cloned from animals bearing UV-induced skin tumors. These cells were I-J+, CD4-, CD8-, and had become growth factor independent. Extracts, but not supernatants, of these clones suppressed primary immune reactions in vitro against UV-induced tumors, but not methylcholanthrene-induced tumors. The cells therefore had the functional characteristics of afferent suppressor T cells directed against a common Ag on UV-induced tumors. Surface iodination of the clones revealed an extremely low level expression of molecules that might be TCR or related molecules.
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Database:
MEDLINE
Main subject:
T-Lymphocytes, Regulatory
/
Neoplasms, Experimental
Limits:
Animals
Language:
En
Year:
1990
Type:
Article