The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin.

Schemann, Michael; Hafsi, Nadia; Michel, Klaus; Kober, Olivia I; Wollmann, Jutta; Li, Qin; Zeller, Florian; Langer, Rupert; Lee, Kevin; Cellek, Selim

Schemann, Michael; Hafsi, Nadia; Michel, Klaus; Kober, Olivia I; Wollmann, Jutta; Li, Qin; Zeller, Florian; Langer, Rupert; Lee, Kevin; Cellek, Selim.

Affiliation

Schemann M; Human Biology, Technische Universität München, Freising, Germany.

Gastroenterology ; 138(1): 266-74, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19786030

Subject(s)

Adrenergic beta-3 Receptor Agonists; Aniline Compounds/pharmacology; Benzoates/pharmacology; Neurons/drug effects; Somatostatin/metabolism; Submucous Plexus/cytology; Action Potentials/drug effects; Adipocytes/drug effects; Adipocytes/metabolism; Adrenergic beta-3 Receptor Antagonists; Aged; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Ganglionic Stimulants/pharmacology; Humans; In Vitro Techniques; Intestines/innervation; Male; Middle Aged; Myenteric Plexus/cytology; Neurons/physiology; Nicotine/pharmacology; Propanolamines/pharmacology; Receptors, Adrenergic, beta-3/metabolism

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Full text: 1 Database: MEDLINE Main subject: Submucous Plexus / Benzoates / Somatostatin / Adrenergic beta-3 Receptor Agonists / Aniline Compounds / Neurons Limits: Aged / Female / Humans / Male / Middle aged Language: En Year: 2010 Type: Article

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