Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.

DeMeo, Dawn L; Mariani, Thomas; Bhattacharya, Soumyaroop; Srisuma, Sorachai; Lange, Christoph; Litonjua, Augusto; Bueno, Raphael; Pillai, Sreekumar G; Lomas, David A; Sparrow, David; Shapiro, Steven D; Criner, Gerard J; Kim, Hong P; Chen, Zhihua; Choi, Augustine M K; Reilly, John; Silverman, Edwin K

DeMeo, Dawn L; Mariani, Thomas; Bhattacharya, Soumyaroop; Srisuma, Sorachai; Lange, Christoph; Litonjua, Augusto; Bueno, Raphael; Pillai, Sreekumar G; Lomas, David A; Sparrow, David; Shapiro, Steven D; Criner, Gerard J; Kim, Hong P; Chen, Zhihua; Choi, Augustine M K; Reilly, John; Silverman, Edwin K.

Affiliation

DeMeo DL; Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. dawn.demeo@channing.harvard.edu

Am J Hum Genet ; 85(4): 493-502, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19800047

Subject(s)

Genetic Predisposition to Disease; Iron Regulatory Protein 2/genetics; Pulmonary Disease, Chronic Obstructive/genetics; Aged; Case-Control Studies; Cohort Studies; Epithelial Cells/metabolism; Family Health; Female; Gene Expression Profiling; Genomics; Humans; Lung/metabolism; Male; Middle Aged; Models, Genetic; Polymorphism, Single Nucleotide; Pulmonary Disease, Chronic Obstructive/diagnosis

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Full text: 1 Database: MEDLINE Main subject: Genetic Predisposition to Disease / Pulmonary Disease, Chronic Obstructive / Iron Regulatory Protein 2 Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Year: 2009 Type: Article

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