A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab.

Hong, Kwang-Won; Kim, Chang-Goo; Lee, Seung-Hyun; Chang, Ki-Hwan; Shin, Yong Won; Ryoo, Kyung-Hwan; Kim, Se-Ho; Kim, Yong-Sung

Hong, Kwang-Won; Kim, Chang-Goo; Lee, Seung-Hyun; Chang, Ki-Hwan; Shin, Yong Won; Ryoo, Kyung-Hwan; Kim, Se-Ho; Kim, Yong-Sung.

Affiliation

Hong KW; Central Research Center, Green Cross Corp., Bojung-dong, Giheung-gu, Yongin City, Gyunggi-Do, Republic of Korea.

J Biotechnol ; 145(1): 84-91, 2010 Jan 01.

Article in En | MEDLINE | ID: mdl-19828124

Subject(s)

Antibodies, Monoclonal/pharmacology; Epitopes/immunology; ErbB Receptors/antagonists & inhibitors; Neoplasms/drug therapy; Amino Acid Sequence; Animals; Antibodies, Monoclonal/biosynthesis; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal, Humanized; Base Sequence; Binding Sites, Antibody; Cell Line, Tumor; Cell Proliferation/drug effects; Cetuximab; Epidermal Growth Factor/metabolism; Epitope Mapping; ErbB Receptors/immunology; ErbB Receptors/metabolism; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms/enzymology; Neoplasms/immunology; Neoplasms/pathology; Phosphorylation; Uterine Cervical Neoplasms/immunology

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Full text: 1 Database: MEDLINE Main subject: ErbB Receptors / Antibodies, Monoclonal / Epitopes / Neoplasms Limits: Animals / Female / Humans / Male Language: En Year: 2010 Type: Article

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