Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

Yin, Bu; Savic, Velibor; Juntilla, Marisa M; Bredemeyer, Andrea L; Yang-Iott, Katherine S; Helmink, Beth A; Koretzky, Gary A; Sleckman, Barry P; Bassing, Craig H

Yin, Bu; Savic, Velibor; Juntilla, Marisa M; Bredemeyer, Andrea L; Yang-Iott, Katherine S; Helmink, Beth A; Koretzky, Gary A; Sleckman, Barry P; Bassing, Craig H.

Affiliation

Yin B; Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

J Exp Med ; 206(12): 2625-39, 2009 Nov 23.

Article in En | MEDLINE | ID: mdl-19887394

Subject(s)

Chromatin/metabolism; Chromosome Breakage; DNA Breaks, Double-Stranded; Histones/metabolism; Recombination, Genetic/physiology; VDJ Exons/physiology; Animals; Ataxia Telangiectasia Mutated Proteins; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/immunology; Cell Cycle Proteins/metabolism; Cell Line, Transformed; Chromatin/genetics; Chromatin/immunology; G1 Phase/physiology; Histones/genetics; Histones/immunology; Mice; Mice, Knockout; Phosphorylation/physiology; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/immunology; Protein Serine-Threonine Kinases/metabolism; Quantitative Trait Loci/physiology; Receptors, Antigen, B-Cell/genetics; Receptors, Antigen, B-Cell/immunology; Receptors, Antigen, B-Cell/metabolism; Receptors, Antigen, T-Cell, alpha-beta/genetics; Receptors, Antigen, T-Cell, alpha-beta/immunology; Receptors, Antigen, T-Cell, alpha-beta/metabolism

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Full text: 1 Database: MEDLINE Main subject: Recombination, Genetic / Chromatin / Histones / Chromosome Breakage / VDJ Exons / DNA Breaks, Double-Stranded Limits: Animals Language: En Year: 2009 Type: Article

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