AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.

Ovens, Matthew J; Davies, Andrew J; Wilson, Marieangela C; Murray, Clare M; Halestrap, Andrew P

Ovens, Matthew J; Davies, Andrew J; Wilson, Marieangela C; Murray, Clare M; Halestrap, Andrew P.

Affiliation

Ovens MJ; Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.

Biochem J ; 425(3): 523-30, 2010 Jan 15.

Article in En | MEDLINE | ID: mdl-19929853

Subject(s)

Monocarboxylic Acid Transporters/antagonists & inhibitors; Symporters/antagonists & inhibitors; Thiophenes/pharmacology; Uracil/analogs & derivatives; Animals; Binding Sites; Catalytic Domain; Chickens; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocytes/metabolism; Phenylalanine/chemistry; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Uracil/pharmacology; Xenopus laevis/metabolism

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Full text: 1 Database: MEDLINE Main subject: Thiophenes / Uracil / Monocarboxylic Acid Transporters / Symporters Limits: Animals Language: En Year: 2010 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Thiophenes / Uracil / Monocarboxylic Acid Transporters / Symporters Limits: Animals Language: En Year: 2010 Type: Article