Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice.

Musteanu, Monica; Blaas, Leander; Mair, Markus; Schlederer, Michaela; Bilban, Martin; Tauber, Stefanie; Esterbauer, Harald; Mueller, Mathias; Casanova, Emilio; Kenner, Lukas; Poli, Valeria; Eferl, Robert

Musteanu, Monica; Blaas, Leander; Mair, Markus; Schlederer, Michaela; Bilban, Martin; Tauber, Stefanie; Esterbauer, Harald; Mueller, Mathias; Casanova, Emilio; Kenner, Lukas; Poli, Valeria; Eferl, Robert.

Affiliation

Musteanu M; Ludwig Boltzmann Institute for Cancer Research, A-1090 Vienna, Austria.

Gastroenterology ; 138(3): 1003-11.e1-5, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19962983

Subject(s)

Adenomatous Polyposis Coli/metabolism; Carcinoma/metabolism; Cell Transformation, Neoplastic/metabolism; Colorectal Neoplasms/metabolism; Genes, APC; STAT3 Transcription Factor/metabolism; Signal Transduction; Adenomatous Polyposis Coli/genetics; Adenomatous Polyposis Coli/pathology; Animals; Carcinoembryonic Antigen/metabolism; Carcinoma/genetics; Carcinoma/pathology; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Colorectal Neoplasms/genetics; Colorectal Neoplasms/pathology; Disease Models, Animal; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Neoplasm Invasiveness; STAT3 Transcription Factor/deficiency; STAT3 Transcription Factor/genetics; Signal Transduction/genetics; Time Factors; beta Catenin/metabolism

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Full text: 1 Database: MEDLINE Main subject: Carcinoma / Colorectal Neoplasms / Signal Transduction / Cell Transformation, Neoplastic / Genes, APC / Adenomatous Polyposis Coli / STAT3 Transcription Factor Type of study: Prognostic_studies Limits: Animals Language: En Year: 2010 Type: Article

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