Myofibroblasts generated in culture from sclerotic skin lesions of a patient with extensive chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation are of recipient origin.
Stem Cells Dev
; 19(9): 1285-7, 2010 Sep.
Article
in En
| MEDLINE
| ID: mdl-20001597
ABSTRACT
Abstract The origin (recipient/donor) of the myofibroblasts mediating fibrosis in sclerodermatous chronic graft-versus-host disease (cGvHD) was investigated. Sclerodermatous specimens obtained from a patient with extensive cGvHD after an HLA-identical sibling bone marrow transplantation were cultured in order to derive tissue myofibroblasts. All proliferating a-SMA+ fibroblastoid cells revealed recipient origin as examined by variable number tandem repeat (VNTR)-PCR. This case report shows that fibrosis in sclerodermatous lesions results from the activation and proliferation of locally-derived recipient fibroblasts rather than from donor-derived fibroblasts or circulating fibrocytes.
Full text:
1
Database:
MEDLINE
Main subject:
Skin Diseases
/
Hematopoietic Stem Cell Transplantation
/
Myofibroblasts
/
Graft vs Host Disease
Limits:
Humans
Language:
En
Year:
2010
Type:
Article