Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

Galanty, Yaron; Belotserkovskaya, Rimma; Coates, Julia; Polo, Sophie; Miller, Kyle M; Jackson, Stephen P

Galanty, Yaron; Belotserkovskaya, Rimma; Coates, Julia; Polo, Sophie; Miller, Kyle M; Jackson, Stephen P.

Affiliation

Galanty Y; The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Nature ; 462(7275): 935-9, 2009 Dec 17.

Article in En | MEDLINE | ID: mdl-20016603

Subject(s)

DNA Breaks, Double-Stranded; DNA Repair; Protein Inhibitors of Activated STAT/metabolism; Small Ubiquitin-Related Modifier Proteins/metabolism; Animals; BRCA1 Protein/metabolism; Cell Line; Cell Line, Tumor; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Fluorescence Recovery After Photobleaching; Humans; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Models, Biological; Phosphorylation; Protein Inhibitors of Activated STAT/chemistry; Protein Inhibitors of Activated STAT/genetics; Protein Structure, Tertiary; Replication Protein A/metabolism; Small Ubiquitin-Related Modifier Proteins/genetics; Ubiquitin-Conjugating Enzymes/genetics; Ubiquitin-Conjugating Enzymes/metabolism; Ubiquitin-Protein Ligases/metabolism; Ubiquitination

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Full text: 1 Database: MEDLINE Main subject: Small Ubiquitin-Related Modifier Proteins / DNA Repair / Protein Inhibitors of Activated STAT / DNA Breaks, Double-Stranded Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2009 Type: Article

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