Premature menopause because of an inherited deletion in the long arm of the X-chromosome.
Fertil Steril
; 55(3): 631-3, 1991 Mar.
Article
in En
| MEDLINE
| ID: mdl-2001764
ABSTRACT
A family is described in which both a mother and an infertile daughter had premature menopause at the ages of 31 and 28 years, respectively. Initially, an extensive investigation revealed no apparent cause for their conditions. However, when cytogenetic analysis in the daughter was performed, a terminal deletion in the long arm of one of the X-chromosomes was found. The karyotype was 46,Xdel(X),(q25-qter). Chromosomal investigation in the mother showed an identical deletion. The karyotype of the patient's 35-year-old sister is normal. She has a normal menstrual cycle and two normal children. The presence of such familial cases suggests that chromosomal investigation should be considered in young women with oligomenorrhea, especially those whose mothers have experienced a premature menopause.
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Database:
MEDLINE
Main subject:
X Chromosome
/
Menopause, Premature
/
Chromosome Deletion
Limits:
Adult
/
Female
/
Humans
Language:
En
Year:
1991
Type:
Article