Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos.

Pantaleon, Marie; Tan, Hwee Y; Kafer, Georgia R; Kaye, Peter L

Pantaleon, Marie; Tan, Hwee Y; Kafer, Georgia R; Kaye, Peter L.

Affiliation

Pantaleon M; The University of Queensland School of Biomedical Sciences, Brisbane, Queensland 4072, Australia. m.pantaleon@uq.edu.au

Biol Reprod ; 82(4): 751-8, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20032283

Subject(s)

Embryo, Mammalian/metabolism; Hexosamines/metabolism; Hyperglycemia/complications; Hyperglycemia/metabolism; Acetylglucosaminidase/immunology; Acetylglucosaminidase/metabolism; Animals; Antibodies/pharmacology; Carbohydrate Metabolism/drug effects; Carbohydrate Metabolism/physiology; Embryo, Mammalian/drug effects; Embryonic Development/drug effects; Embryonic Development/physiology; Enzyme Activation/drug effects; Female; Gestational Age; Glycosylation/drug effects; Hyperglycemia/pathology; Maternal-Fetal Exchange/physiology; Mice; Models, Biological; N-Acetylglucosaminyltransferases/immunology; N-Acetylglucosaminyltransferases/metabolism; Pregnancy; Pregnancy Complications/metabolism; Pregnancy Complications/pathology; Signal Transduction/drug effects; Signal Transduction/physiology

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Full text: 1 Database: MEDLINE Main subject: Embryo, Mammalian / Hexosamines / Hyperglycemia Limits: Animals / Pregnancy Language: En Year: 2010 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Embryo, Mammalian / Hexosamines / Hyperglycemia Limits: Animals / Pregnancy Language: En Year: 2010 Type: Article