Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond.

Ferrante, Andrea; Gorski, Jack

Ferrante, Andrea; Gorski, Jack.

Affiliation

Ferrante A; Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA. andrea.ferrante@bcw.edu

J Immunol ; 184(3): 1153-8, 2010 Feb 01.

Article in En | MEDLINE | ID: mdl-20038641

Subject(s)

Conserved Sequence; HLA-D Antigens/physiology; Multiprotein Complexes/physiology; Peptide Fragments/metabolism; Amino Acid Substitution/genetics; Amino Acid Substitution/immunology; Binding, Competitive/genetics; Binding, Competitive/immunology; Cell Line; Conserved Sequence/genetics; HLA-D Antigens/metabolism; HLA-DR1 Antigen/genetics; HLA-DR1 Antigen/metabolism; Hemagglutinin Glycoproteins, Influenza Virus/genetics; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Hemagglutinin Glycoproteins, Influenza Virus/physiology; Humans; Hydrogen Bonding; Influenza A virus/immunology; Ligands; Multiprotein Complexes/genetics; Multiprotein Complexes/metabolism; Mutagenesis, Site-Directed; Peptide Fragments/genetics; Peptide Fragments/physiology; Protein Binding/genetics; Protein Binding/immunology; Protein Conformation; Protein Folding; Protein Stability

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Peptide Fragments / HLA-D Antigens / Conserved Sequence / Multiprotein Complexes Limits: Humans Language: En Year: 2010 Type: Article

Fulltext

XML

PubMed Links

Search on Google