TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.

Yang-Iott, Katherine S; Carpenter, Andrea C; Rowh, Marta A W; Steinel, Natalie; Brady, Brenna L; Hochedlinger, Konrad; Jaenisch, Rudolf; Bassing, Craig H

Yang-Iott, Katherine S; Carpenter, Andrea C; Rowh, Marta A W; Steinel, Natalie; Brady, Brenna L; Hochedlinger, Konrad; Jaenisch, Rudolf; Bassing, Craig H.

Affiliation

Yang-Iott KS; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

J Immunol ; 184(3): 1369-78, 2010 Feb 01.

Article in En | MEDLINE | ID: mdl-20042591

Subject(s)

Antibody Diversity; Chromatin/physiology; Feedback, Physiological/physiology; Gene Rearrangement, T-Lymphocyte/immunology; Immunoglobulin Joining Region; Receptors, Antigen, T-Cell, alpha-beta/antagonists & inhibitors; Receptors, Antigen, T-Cell, alpha-beta/metabolism; Signal Transduction/immunology; Animals; Antibody Diversity/genetics; Cell Differentiation/genetics; Cell Differentiation/immunology; Gene Expression Regulation, Developmental/immunology; Genes, Reporter/immunology; Germ-Line Mutation/immunology; Immunoglobulin Joining Region/genetics; Immunoglobulin Variable Region/genetics; Loss of Heterozygosity/immunology; Mice; Mice, Transgenic; Receptors, Antigen, T-Cell, alpha-beta/biosynthesis; Receptors, Antigen, T-Cell, alpha-beta/genetics; Signal Transduction/genetics; T-Lymphocyte Subsets/cytology; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism

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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin Joining Region / Chromatin / Gene Rearrangement, T-Lymphocyte / Signal Transduction / Receptors, Antigen, T-Cell, alpha-beta / Feedback, Physiological / Antibody Diversity Type of study: Prognostic_studies Limits: Animals Language: En Year: 2010 Type: Article

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