Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of &#916;F508 cystic fibrosis transmembrane conductance regulator rescue.

Pyle, Louise C; Fulton, Jennifer C; Sloane, Peter A; Backer, Kyle; Mazur, Marina; Prasain, Jeevan; Barnes, Stephen; Clancy, J P; Rowe, Steven M

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescue.

Pyle, Louise C; Fulton, Jennifer C; Sloane, Peter A; Backer, Kyle; Mazur, Marina; Prasain, Jeevan; Barnes, Stephen; Clancy, J P; Rowe, Steven M.

Affiliation

Pyle LC; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Am J Respir Cell Mol Biol ; 43(5): 607-16, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20042712

Subject(s)

Biomarkers/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Ion Channel Gating/drug effects; Mutant Proteins/metabolism; Quercetin/pharmacology; Animals; Cell Membrane/drug effects; Cell Membrane/metabolism; Chlorides/metabolism; Cyclic AMP/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/chemistry; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Ion Transport/drug effects; Membrane Potentials/drug effects; Mice; Mutant Proteins/chemistry; NIH 3T3 Cells; Nasal Mucosa/drug effects; Nasal Mucosa/metabolism; Phosphorylation/drug effects; Protein Structure, Tertiary; Rats; Receptors, Adrenergic, beta-2/metabolism

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Full text: 1 Database: MEDLINE Main subject: Quercetin / Biomarkers / Ion Channel Gating / Cystic Fibrosis Transmembrane Conductance Regulator / Mutant Proteins Limits: Animals / Humans Language: En Year: 2010 Type: Article

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