Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2.

Tong, Hua Hua; Li, Yong Xing; Stahl, Gregory L; Thurman, Joshua M

Tong, Hua Hua; Li, Yong Xing; Stahl, Gregory L; Thurman, Joshua M.

Affiliation

Tong HH; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, 4024 Cramblett Hall, Columbus, OH 43210, USA. tong.1@osu.edu

Infect Immun ; 78(3): 976-83, 2010 Mar.

Article in En | MEDLINE | ID: mdl-20065024

Subject(s)

Complement C1q/immunology; Complement C2/immunology; Complement Factor B/immunology; Disease Susceptibility; Otitis Media/immunology; Pneumococcal Infections/immunology; Streptococcus pneumoniae/immunology; Animals; Bacteremia/immunology; Bacteremia/microbiology; Blood Bactericidal Activity; Colony Count, Microbial; Complement C1q/deficiency; Complement C2/deficiency; Complement Factor B/deficiency; Ear, Middle/microbiology; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbial Viability; Opsonin Proteins/immunology; Otitis Media/genetics; Phagocytosis/immunology; Pneumococcal Infections/complications; Pneumococcal Infections/genetics

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Full text: 1 Database: MEDLINE Main subject: Otitis Media / Pneumococcal Infections / Streptococcus pneumoniae / Complement C2 / Complement Factor B / Complement C1q / Disease Susceptibility Limits: Animals Language: En Year: 2010 Type: Article

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