Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

Debenham, John S; Madsen-Duggan, Christina B; Toupence, Richard B; Walsh, Thomas F; Wang, Junying; Tong, Xinchun; Kumar, Sanjeev; Lao, Julie; Fong, Tung M; Xiao, Jing Chen; Huang, Cathy R-R C; Shen, Chun-Pyn; Feng, Yue; Marsh, Donald J; Stribling, D Sloan; Shearman, Lauren P; Strack, Alison M; Goulet, Mark T

Debenham, John S; Madsen-Duggan, Christina B; Toupence, Richard B; Walsh, Thomas F; Wang, Junying; Tong, Xinchun; Kumar, Sanjeev; Lao, Julie; Fong, Tung M; Xiao, Jing Chen; Huang, Cathy R-R C; Shen, Chun-Pyn; Feng, Yue; Marsh, Donald J; Stribling, D Sloan; Shearman, Lauren P; Strack, Alison M; Goulet, Mark T.

Affiliation

Debenham JS; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. john_debenham@merck.com

Bioorg Med Chem Lett ; 20(4): 1448-52, 2010 Feb 15.

Article in En | MEDLINE | ID: mdl-20096577

Subject(s)

Drug Design; Furans/chemical synthesis; Pyridines/chemical synthesis; Receptor, Cannabinoid, CB1/agonists; Animals; Benzopyrans; Dogs; Furans/chemistry; Furans/pharmacology; Haplorhini; Humans; Inhibitory Concentration 50; Mice; Mice, Knockout; Molecular Structure; Pyridines/chemistry; Pyridines/pharmacology; Rats; Receptor, Cannabinoid, CB1/genetics; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Pyridines / Drug Design / Receptor, Cannabinoid, CB1 / Furans Limits: Animals / Humans Language: En Year: 2010 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Pyridines / Drug Design / Receptor, Cannabinoid, CB1 / Furans Limits: Animals / Humans Language: En Year: 2010 Type: Article