Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

Mustafa, Asif K; Ahmad, Abdullah S; Zeynalov, Emil; Gazi, Sadia K; Sikka, Gautam; Ehmsen, Jeffrey T; Barrow, Roxanne K; Coyle, Joseph T; Snyder, Solomon H; Doré, Sylvain

Mustafa, Asif K; Ahmad, Abdullah S; Zeynalov, Emil; Gazi, Sadia K; Sikka, Gautam; Ehmsen, Jeffrey T; Barrow, Roxanne K; Coyle, Joseph T; Snyder, Solomon H; Doré, Sylvain.

Affiliation

Mustafa AK; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

J Neurosci ; 30(4): 1413-6, 2010 Jan 27.

Article in En | MEDLINE | ID: mdl-20107067

Subject(s)

Brain Ischemia/enzymology; Brain Ischemia/genetics; Cytoprotection/genetics; Neurotoxins/metabolism; Racemases and Epimerases/genetics; Serine/metabolism; Animals; Brain/blood supply; Brain/enzymology; Brain/physiopathology; Brain Infarction/enzymology; Brain Infarction/genetics; Brain Infarction/therapy; Brain Ischemia/therapy; Cells, Cultured; Disease Models, Animal; Down-Regulation/genetics; Gene Deletion; Gene Expression Regulation, Enzymologic/genetics; Genetic Therapy/methods; Infarction, Middle Cerebral Artery/enzymology; Infarction, Middle Cerebral Artery/genetics; Infarction, Middle Cerebral Artery/therapy; Isomerism; Male; Mice; Mice, Knockout; Nitric Oxide/metabolism; Nitric Oxide Synthase Type I/genetics; Nitro Compounds/metabolism; Receptors, N-Methyl-D-Aspartate/agonists; Receptors, N-Methyl-D-Aspartate/metabolism

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Full text: 1 Database: MEDLINE Main subject: Serine / Brain Ischemia / Racemases and Epimerases / Cytoprotection / Neurotoxins Limits: Animals Language: En Year: 2010 Type: Article

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