DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

Aleyasin, Hossein; Rousseaux, Maxime W C; Marcogliese, Paul C; Hewitt, Sarah J; Irrcher, Isabella; Joselin, Alvin P; Parsanejad, Mohammad; Kim, Raymond H; Rizzu, Patrizia; Callaghan, Steve M; Slack, Ruth S; Mak, Tak W; Park, David S

Aleyasin, Hossein; Rousseaux, Maxime W C; Marcogliese, Paul C; Hewitt, Sarah J; Irrcher, Isabella; Joselin, Alvin P; Parsanejad, Mohammad; Kim, Raymond H; Rizzu, Patrizia; Callaghan, Steve M; Slack, Ruth S; Mak, Tak W; Park, David S.

Affiliation

Aleyasin H; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Proc Natl Acad Sci U S A ; 107(7): 3186-91, 2010 Feb 16.

Article in En | MEDLINE | ID: mdl-20133695

Subject(s)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/metabolism; Neurotoxins/metabolism; Oncogene Proteins/metabolism; Oxidative Stress/physiology; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/physiology; Analysis of Variance; Animals; Blotting, Western; Cell Fractionation; Cells, Cultured; Hydrogen Peroxide/metabolism; Immunohistochemistry; Mice; Neurons/metabolism; Peroxiredoxins; Phosphorylation; Protein Deglycase DJ-1

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Oncogene Proteins / Oxidative Stress / Proto-Oncogene Proteins c-akt / Neurotoxins Limits: Animals Language: En Year: 2010 Type: Article

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