TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

Huppa, Johannes B; Axmann, Markus; Mörtelmaier, Manuel A; Lillemeier, Björn F; Newell, Evan W; Brameshuber, Mario; Klein, Lawrence O; Schütz, Gerhard J; Davis, Mark M

Huppa, Johannes B; Axmann, Markus; Mörtelmaier, Manuel A; Lillemeier, Björn F; Newell, Evan W; Brameshuber, Mario; Klein, Lawrence O; Schütz, Gerhard J; Davis, Mark M.

Affiliation

Huppa JB; Department of Microbiology and Immunology, Stanford School of Medicine, California 94305-5323, USA.

Nature ; 463(7283): 963-7, 2010 Feb 18.

Article in En | MEDLINE | ID: mdl-20164930

Subject(s)

Histocompatibility Antigens Class I/metabolism; Immunological Synapses/immunology; Immunological Synapses/metabolism; Peptides/immunology; Peptides/metabolism; Receptors, Antigen, T-Cell/metabolism; Actins/metabolism; Animals; CD4 Antigens/drug effects; CD4 Antigens/metabolism; Cell Line; Cells, Cultured; Cytoskeleton/metabolism; Drosophila melanogaster; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Histocompatibility Antigens Class I/immunology; Immunological Synapses/drug effects; Kinetics; Ligands; Mice; Mice, Transgenic; Protein Binding/drug effects; Receptors, Antigen, T-Cell/immunology; Signal Transduction; Surface Plasmon Resonance; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/metabolism

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Full text: 1 Database: MEDLINE Main subject: Peptides / Receptors, Antigen, T-Cell / Histocompatibility Antigens Class I / Immunological Synapses Limits: Animals Language: En Year: 2010 Type: Article

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