Continuous solid-phase extraction and gas chromatography-mass spectrometry determination of pharmaceuticals and hormones in water samples.
J Chromatogr A
; 1217(17): 2956-63, 2010 Apr 23.
Article
in En
| MEDLINE
| ID: mdl-20299021
ABSTRACT
A semi-automatic flow-based method for the simultaneous determination of 9 pharmaceuticals and 3 hormones in water samples in a single analytical run is proposed. The analytes were retained on a solid-phase extraction sorbent column and 1 microL of the eluate analysed by gas chromatography in combination with electron impact ionization mass spectrometry in the SIM mode. The sorbent used, Oasis-HLB, provided near-quantitative recovery of all analytes. The proposed method was validated with quite good analytical results including low limits of detection (0.01-0.06 ng L(-1) for 100 mL of water) and good linearity (r2>0.993) throughout the studied concentration ranges. The method provided good accuracy (recoveries of 85-103%) and precision (between- and within-day RSD values less than 7%) in the determination of the pharmaceuticals and hormones in tap, river, pond, well, swimming pool and wastewater.
Full text:
1
Database:
MEDLINE
Main subject:
Water Pollutants, Chemical
/
Pharmaceutical Preparations
/
Environmental Monitoring
/
Solid Phase Extraction
/
Hormones
/
Gas Chromatography-Mass Spectrometry
Type of study:
Evaluation_studies
Language:
En
Year:
2010
Type:
Article