Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.

Hadden, Mark; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Henderson, Alan J; Pattamana, Kevin; Ruenz, Megan; Sargent, Bruce J; Swenson, Brian; Yet, Larry; Liu, Jian; He, Shuwen; Sebhat, Iyassu K; Lin, Linus S; Tamvakopoulos, Constantin; Peng, Qianping; Kan, Yanqing; Palyha, Oksana; Kelly, Theresa M; Guan, Xiao-Ming; Metzger, Joseph M; Reitman, Marc L; Nargund, Ravi P

Hadden, Mark; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Henderson, Alan J; Pattamana, Kevin; Ruenz, Megan; Sargent, Bruce J; Swenson, Brian; Yet, Larry; Liu, Jian; He, Shuwen; Sebhat, Iyassu K; Lin, Linus S; Tamvakopoulos, Constantin; Peng, Qianping; Kan, Yanqing; Palyha, Oksana; Kelly, Theresa M; Guan, Xiao-Ming; Metzger, Joseph M; Reitman, Marc L; Nargund, Ravi P.

Affiliation

Hadden M; AMRI, 26 Corporate Circle, Albany, NY 12212, USA. mark.hadden@amriglobal.com

Bioorg Med Chem Lett ; 20(9): 2912-5, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20347296

Subject(s)

Anti-Obesity Agents/chemical synthesis; Imidazoles/chemistry; Receptors, Bombesin/agonists; Administration, Oral; Animals; Anti-Obesity Agents/chemistry; Anti-Obesity Agents/therapeutic use; Brain/metabolism; Humans; Imidazoles/chemical synthesis; Imidazoles/therapeutic use; Mice; Obesity/drug therapy; Rats; Receptors, Bombesin/metabolism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Receptors, Bombesin / Anti-Obesity Agents / Imidazoles Limits: Animals / Humans Language: En Year: 2010 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, Bombesin / Anti-Obesity Agents / Imidazoles Limits: Animals / Humans Language: En Year: 2010 Type: Article