Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.

Honoré, Jean-Claude; Kooli, Amna; Hou, Xin; Hamel, David; Rivera, José Carlos; Picard, Emilie; Hardy, Pierre; Tremblay, Sophie; Varma, Daya R; Jankov, Robert P; Mancini, Joseph A; Balazy, Michael; Chemtob, Sylvain

Honoré, Jean-Claude; Kooli, Amna; Hou, Xin; Hamel, David; Rivera, José Carlos; Picard, Emilie; Hardy, Pierre; Tremblay, Sophie; Varma, Daya R; Jankov, Robert P; Mancini, Joseph A; Balazy, Michael; Chemtob, Sylvain.

Affiliation

Honoré JC; Department of Pediatrics, Research Center-Centre Hospitalier Universitaire Ste-Justine, Montréal, Quebec, Canada.

Am J Physiol Regul Integr Comp Physiol ; 298(6): R1522-30, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20357019

Subject(s)

Brain/metabolism; Hypercapnia/metabolism; Neurodegenerative Diseases/metabolism; Nitrates/metabolism; Animals; Animals, Newborn; Nitric Oxide Synthase Type III/metabolism; Nitrites/metabolism; Nitroarginine/metabolism; Oxygen/metabolism; Rats; Rats, Sprague-Dawley; Tyrosine/analogs & derivatives; Tyrosine/metabolism

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Full text: 1 Database: MEDLINE Main subject: Brain / Neurodegenerative Diseases / Hypercapnia / Nitrates Limits: Animals Language: En Year: 2010 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Brain / Neurodegenerative Diseases / Hypercapnia / Nitrates Limits: Animals Language: En Year: 2010 Type: Article