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Drugging drug resistance.
Dannenberg, Jan-Hermen; Berns, Anton.
Affiliation
  • Dannenberg JH; Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Cell ; 141(1): 18-20, 2010 Apr 02.
Article in En | MEDLINE | ID: mdl-20371339
ABSTRACT
Resistance to anticancer drugs is widely observed in vitro and in cancer patients, but its prevalence is too high to be solely explained by the acquisition of mutations. Sharma et al. (2010) now report that dynamic chromatin modifications may be an independent route to drug resistance in cancer cells that can be reversed by epigenetic drugs.

Full text: 1 Database: MEDLINE Type of study: Risk_factors_studies Language: En Year: 2010 Type: Article

Full text: 1 Database: MEDLINE Type of study: Risk_factors_studies Language: En Year: 2010 Type: Article