Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.

Suh, Jaehong; Im, Doo Soon; Moon, Gyeong Joon; Ryu, Keun Sil; de Silva, Rohan; Choi, In Sun; Lees, Andrew J; Guénette, Suzanne Y; Tanzi, Rudolph E; Gwag, Byoung Joo

Suh, Jaehong; Im, Doo Soon; Moon, Gyeong Joon; Ryu, Keun Sil; de Silva, Rohan; Choi, In Sun; Lees, Andrew J; Guénette, Suzanne Y; Tanzi, Rudolph E; Gwag, Byoung Joo.

Affiliation

Suh J; Department of Pharmacology, Ajou University School of Medicine, Suwon 442-749, Korea.

J Neurochem ; 114(1): 160-70, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20374429

Subject(s)

Hypoxia-Ischemia, Brain/metabolism; Ischemic Attack, Transient/metabolism; Proteasome Endopeptidase Complex/physiology; tau Proteins/metabolism; Alternative Splicing; Animals; Cells, Cultured; Cerebral Cortex/metabolism; Exons; Male; Neurons/metabolism; Nuclear Proteins/metabolism; Phosphorylation; Proteasome Inhibitors; Protein Isoforms/genetics; Protein Isoforms/metabolism; RNA-Binding Proteins/metabolism; Rats; Rats, Sprague-Dawley; Serine-Arginine Splicing Factors; Ubiquitination; tau Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Ischemic Attack, Transient / Tau Proteins / Hypoxia-Ischemia, Brain / Proteasome Endopeptidase Complex Limits: Animals Language: En Year: 2010 Type: Article

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