Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin.

Yokoyama, Hitoshi; Sasaki, Katsumi; Franks, Michael E; Goins, William F; Goss, James R; de Groat, William C; Glorioso, Joseph C; Chancellor, Michael B; Yoshimura, Naoki

Yokoyama, Hitoshi; Sasaki, Katsumi; Franks, Michael E; Goins, William F; Goss, James R; de Groat, William C; Glorioso, Joseph C; Chancellor, Michael B; Yoshimura, Naoki.

Affiliation

Yokoyama H; Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Hum Gene Ther ; 20(1): 63-71, 2009 Jan.

Article in En | MEDLINE | ID: mdl-20377371

Subject(s)

Cystitis, Interstitial/therapy; Enkephalins/metabolism; Genetic Therapy/methods; Genetic Vectors/genetics; Protein Precursors/metabolism; Simplexvirus/genetics; Animals; Cystitis, Interstitial/genetics; Disease Models, Animal; Enkephalins/genetics; Female; Ganglia, Spinal/metabolism; Genetic Vectors/administration & dosage; Humans; Neurons, Afferent/metabolism; Protein Precursors/genetics; Rats; Rats, Sprague-Dawley; Simplexvirus/metabolism; Treatment Outcome; Urinary Bladder/innervation; Urinary Bladder/pathology

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Full text: 1 Database: MEDLINE Main subject: Protein Precursors / Enkephalins / Genetic Therapy / Simplexvirus / Cystitis, Interstitial / Genetic Vectors Limits: Animals / Female / Humans Language: En Year: 2009 Type: Article

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