Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on In Vitro Mammalian Cell Micronucleus Test.

Cariou, Olivier; Laroche-Prigent, Nathalie; Ledieu, Sandrine; Guizon, Isabelle; Paillard, Françoise; Thybaud, Véronique

Cariou, Olivier; Laroche-Prigent, Nathalie; Ledieu, Sandrine; Guizon, Isabelle; Paillard, Françoise; Thybaud, Véronique.

Affiliation

Cariou O; Drug Safety Evaluation, Sanofi Aventis, Porcheville, France.

Mutat Res ; 702(2): 148-56, 2010 Oct 29.

Article in En | MEDLINE | ID: mdl-20398790

Subject(s)

Micronucleus Tests/methods; Mutagens/toxicity; Animals; Anthracenes/toxicity; Cell Count; Cell Line, Tumor; Cytarabine/toxicity; Fluorouracil/toxicity; France; Guidelines as Topic; Leukemia L5178/genetics; Mice; Micronucleus Tests/standards; Vinblastine/toxicity

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Full text: 1 Database: MEDLINE Main subject: Micronucleus Tests / Mutagens Type of study: Evaluation_studies / Guideline Limits: Animals Country/Region as subject: Europa Language: En Year: 2010 Type: Article

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